Evaluation of cytotoxicity and mechanical properties of fluorapatite-45S5 bioactive glass nanocomposite

The purpose of this study was to fabricate and characterize nanocomposite powder from 45S5 bioactive glass/ fluorapatite. Nanocomposites containing 10, 15 and 20 wt.% of fluorapatite were synthesized by sol-gel method. XRD and FT-IR analyses were used to characterize and evaluate the produced nanocomposites. The results of XRD and FT-IR analysis indicated the successful synthesis of high purity bioactive glass nanocomposites. The results of compressive strength test showed an increase in strength of sample containing 15% fluorapatite. MTT (3-(4,5-Dimethylthiazol-2-Yl)-2,5-Diphenyltetrazolium Bromide) assay was used to evaluate cytotoxicity. The results of this section showed no cytotoxicity of the samples, which showed a decrease in the survival rate after seven days. The lowest survival rate was observed for pure fluorapatite.